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Brain Res. 1986 Feb 12;365(1):70-7.

Effects of gamma-aminobutyric acid on cones and bipolar cells of the tiger salamander retina.


The gamma-aminobutyric acid (GABA) system in the tiger salamander retina was studied using autoradiographic and electrophysiological techniques. A high-affinity uptake mechanism for GABA has been localized in about 60% of the horizontal cells and about 30% of the amacrine cells. Effects of exogeneously applied GABA on the membrane conductance of cones and hyperpolarizing bipolar cells (HBC) were examined using the two electrode current-clamp technique in the living retinal slices. In both cell types, 1 mM of GABA caused a conductance increase. In perfused eyecups, 2 mM of GABA selectivity abolished the surround response of the HBC and left the center response unchanged. These results are consistent with the notion that a population of horizontal cells and a population of amacrine cells in the salamander retina may use GABA as their neurotransmitter.

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