Abstract
Treatment of alkylated HeLa cells with 3-aminobenzamide, an inhibitor of poly(ADP-ribose) polymerase, increased the number of DNA strand breaks but did not affect the rate of strand rejoining. This suggests that an increase in DNA incision, not a decrease in ligation, results from the inhibition of poly(ADP-ribose) polymerase in cells recovering from DNA damaged by alkylating agents.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Alkylation
-
Benzamides / pharmacology
-
Cytarabine / pharmacology
-
DNA / metabolism*
-
DNA Repair* / drug effects
-
DNA, Neoplasm / metabolism
-
HeLa Cells
-
Humans
-
Hydrogen-Ion Concentration
-
Poly(ADP-ribose) Polymerase Inhibitors*
Substances
-
Benzamides
-
DNA, Neoplasm
-
Poly(ADP-ribose) Polymerase Inhibitors
-
Cytarabine
-
3-aminobenzamide
-
DNA