Neurology. 1985 Sep;35(9):1331-4.

Effect of TRH analogs on neurologic recovery after experimental spinal trauma.

Abstract

Effects of two stable TRH analogs were compared after experimental spinal trauma in cats. CG3509, which has a substitution at the amino-terminus of the peptide, improved neurologic recovery; MK771, which has modifications at both ends of the tripeptide, was ineffective. These findings indicate that TRH analogs may be of use in spinal cord injury, and suggest that the C-terminal amino acid may be critical for the beneficial effects of TRH or TRH-analogs in CNS injury.

PMID:: 3927187; [PubMed - indexed for MEDLINE]

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