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Br Med J (Clin Res Ed). 1985 Jun 15;290(6484):1804-6.

Dexamethasone suppression test as a simple measure of stress?

Abstract

Non-suppression of cortisol by dexamethasone has been described as a biological marker of a diagnostic subgroup of depressed patients. This paper presents the hypothesis that the degree of non-suppression is a variable that reflects the quantity of stress or distress experienced by the patient rather than relating to a specific diagnosis. Such a quantitative measure of stress would be valuable for research in general medicine as well as in psychiatry. Testing of this postulate should apply a more precise interpretation of endocrine principles than has been applied to the dexamethasone suppression test to date.

PMID:
3924265
[PubMed - indexed for MEDLINE]
PMCID:
PMC1415944
Free PMC Article
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