Infection. 1979;7 Suppl 5:S443-5.

Efficacy of bacampicillin and ampicillin in experimental pyelonephritis in the rat.

Abstract

Bacampicillin and ampicillin were tested and compared with each other in a model of acute, obstructive pyelonephritis in the rat. The compounds were administered orally at five dose levels ranging from 50 mg/kg to 150 mg/kg. Bacampicillin was found to have a greater therapeutic activity than ampicillin, particulary at the higher doses, indicating that its improved absorption properties make it a therapeutically more effective compound than ampicillin.

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Efficacy of bacampicillin and ampicillin in experimental pyelonephritis in the rat.

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