Abstract
Modulation in sensitivity of dopamine receptors in the central nervous system are reviewed. Three main types differing by their behavioural and biochemical characteristics are described: -- Disuse hypersensitivity to dopamine agonists, induced by an interruption of dopaminergic transmission, seems to depend on an increased number of post-synaptic dopamine receptors; -- Hyposensitivity to dopamine agonists, induced by an overstimulation of dopamine receptors, could depend on their qualitative or quantitative modifications; -- Behavioural facilitation, elicited by a previous administration of dopaminergic agonists in low dosage, could be associated with an hyposensitivity of dopaminergic autoreceptors. They seem to constitute important parameters in adaptation of synaptic efficacy in physiological as well as pathological states.
MeSH terms
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Acetylcholine / physiology
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Adenylyl Cyclases / physiology
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Animals
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Antipsychotic Agents / pharmacology
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Apomorphine / pharmacology
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Behavior / drug effects
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Corpus Striatum / physiology*
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Dogs
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Dopamine / metabolism
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Dopamine Antagonists
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Dose-Response Relationship, Drug
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Dyskinesia, Drug-Induced / physiopathology
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Homovanillic Acid / pharmacology
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Humans
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Hypothermia / chemically induced
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Levodopa / pharmacology
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Memory / drug effects
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Mice
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Opioid-Related Disorders / physiopathology
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Parkinson Disease / physiopathology
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Psychotic Disorders / physiopathology
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Rats
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Receptors, Dopamine / drug effects*
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Sleep / physiology
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Stereotyped Behavior / drug effects
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Substantia Nigra / physiology*
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Synapses / drug effects
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Synapses / physiology
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Synaptic Transmission
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gamma-Aminobutyric Acid / physiology
Substances
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Antipsychotic Agents
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Dopamine Antagonists
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Receptors, Dopamine
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Levodopa
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gamma-Aminobutyric Acid
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Adenylyl Cyclases
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Apomorphine
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Acetylcholine
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Dopamine
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Homovanillic Acid