Neurology. 1985 Mar;35(3):343-51.

Short- and long-term treatment of Tourette's syndrome with clonidine: a clinical perspective.

Leckman JF, Detlor J, Harcherik DF, Ort S, Shaywitz BA, Cohen DJ.

Abstract

Thirteen patients with Gilles de la Tourette's syndrome were treated with clonidine (0.125 to 0.3 mg/d) for at least 60 weeks. In a single-blind, placebo-controlled trial, 6 of the 13 patients were judged to be unequivocal responders to clonidine, and 6 other patients had an equivocal response. There was significant improvement in motor and phonic tics, as well as in associated behavior problems, and there were no serious side effects. Tolerance to clonidine did not develop. Further placebo-controlled, randomized, double-blind studies of clonidine in Tourette's syndrome are needed to establish the drug's efficacy.

PMID:: 3883235; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Treatment of Gilles de la Tourette's syndrome with clonidine and neuroleptics. [Arch Gen Psychiatry. 1983]
Treatment of Gilles de la Tourette's syndrome with clonidine and neuroleptics.
Shapiro AK, Shapiro E, Eisenkraft GJ. Arch Gen Psychiatry. 1983 Nov; 40(11):1235-40.
Clonidine and Gilles de la Tourette's syndrome: double-blind study using objective rating methods. [Ann Neurol. 1987]
Clonidine and Gilles de la Tourette's syndrome: double-blind study using objective rating methods.
Goetz CG, Tanner CM, Wilson RS, Carroll VS, Como PG, Shannon KM. Ann Neurol. 1987 Mar; 21(3):307-10.
Clonidine treatment of Gilles de la Tourette's syndrome. [Arch Gen Psychiatry. 1991]
Clonidine treatment of Gilles de la Tourette's syndrome.
Leckman JF, Hardin MT, Riddle MA, Stevenson J, Ort SI, Cohen DJ. Arch Gen Psychiatry. 1991 Apr; 48(4):324-8.
Review Pimozide for tics in Tourette's syndrome. [Cochrane Database Syst Rev. 2009]
Review Pimozide for tics in Tourette's syndrome.
Pringsheim T, Marras C. Cochrane Database Syst Rev. 2009 Apr 15; (2):CD006996. Epub 2009 Apr 15.
Review Tourette's syndrome: are stimulants safe? [Curr Neurol Neurosci Rep. 2003]
Review Tourette's syndrome: are stimulants safe?
Kurlan R. Curr Neurol Neurosci Rep. 2003 Jul; 3(4):285-8.

See reviews... See all...

Cited by 3 PubMed Central articles

European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment. [Eur Child Adolesc Psychiatry. ...]
European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment.
Roessner V, Plessen KJ, Rothenberger A, Ludolph AG, Rizzo R, Skov L, Strand G, Stern JS, Termine C, Hoekstra PJ, et al. Eur Child Adolesc Psychiatry. 2011 Apr; 20(4):173-96.
Treatment strategies for tics in Tourette syndrome. [Ther Adv Neurol Disord. 2011]
Treatment strategies for tics in Tourette syndrome.
Eddy CM, Rickards HE, Cavanna AE. Ther Adv Neurol Disord. 2011 Jan; 4(1):25-45.
Review Tourette's syndrome: clinical features, pathophysiology, and therapeutic approaches. [Dialogues Clin Neurosci. 2007]
Review Tourette's syndrome: clinical features, pathophysiology, and therapeutic approaches.
Müller N. Dialogues Clin Neurosci. 2007; 9(2):161-71.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Short- and long-term treatment of Tourette's syndrome with clonidine: a clinical...
Short- and long-term treatment of Tourette's syndrome with clonidine: a clinical perspective.
Neurology. 1985 Mar ;35(3):343-51.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Short- and long-term treatment of Tourette's syndrome with clonidine: a clinical perspective.

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 3 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information