Abstract
Using new panels of HLA-DR typing sera, we found an increase in the prevalence of HLA-DR4 in 21 patients with Hashimoto's thyroiditis (57%) and 32 patients with post-partum thyroiditis (53%) compared to controls (21%). Hashimoto's thyroiditis was previously found to be associated with HLA-DR5 and Dw5. We feel that the doubts raised by this study warrant the study of DR antigens in thyroid autoimmune disease using large panels of specific sera.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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Diabetes Mellitus, Type 1 / genetics
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Female
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Genetic Linkage
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Graves Disease / genetics
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HLA-DR4 Antigen
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Histocompatibility Antigens Class II / analysis*
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Humans
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Major Histocompatibility Complex
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Male
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Pedigree
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Pregnancy
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Puerperal Disorders / immunology*
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Thyroiditis / genetics
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Thyroiditis / immunology*
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Thyroiditis, Autoimmune / genetics
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Thyroiditis, Autoimmune / immunology*
Substances
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HLA-DR4 Antigen
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Histocompatibility Antigens Class II