Post-partum thyroiditis and goitrous (Hashimoto's) thyroiditis are associated with HLA-DR4

Immunol Lett. 1985;11(5-6):301-3. doi: 10.1016/0165-2478(85)90111-7.

Abstract

Using new panels of HLA-DR typing sera, we found an increase in the prevalence of HLA-DR4 in 21 patients with Hashimoto's thyroiditis (57%) and 32 patients with post-partum thyroiditis (53%) compared to controls (21%). Hashimoto's thyroiditis was previously found to be associated with HLA-DR5 and Dw5. We feel that the doubts raised by this study warrant the study of DR antigens in thyroid autoimmune disease using large panels of specific sera.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diabetes Mellitus, Type 1 / genetics
  • Female
  • Genetic Linkage
  • Graves Disease / genetics
  • HLA-DR4 Antigen
  • Histocompatibility Antigens Class II / analysis*
  • Humans
  • Major Histocompatibility Complex
  • Male
  • Pedigree
  • Pregnancy
  • Puerperal Disorders / immunology*
  • Thyroiditis / genetics
  • Thyroiditis / immunology*
  • Thyroiditis, Autoimmune / genetics
  • Thyroiditis, Autoimmune / immunology*

Substances

  • HLA-DR4 Antigen
  • Histocompatibility Antigens Class II