T lymphoblastic lymphoma with LEU-7 positive phenotype and unusual clinical course: a multiparameter study

Leuk Res. 1985;9(1):167-73. doi: 10.1016/0145-2126(85)90030-x.

Abstract

Immunologic phenotype studies were performed on cells and on frozen sections of involved tissue from a 20 year old female with typical T-cell lymphoblastic (convoluted) lymphoma. The cells demonstrated a thymic phenotype but in addition marked with Leu-7 (HNK-1)--an antibody reported to identify human natural killer/killer (NK/K) cells. Normal or neoplastic cells with this phenotype have not been previously reported. These findings support the existence of a thymic precursor for a T-cell subset of Leu-7 + cells. The unusual clinical response to therapy is another feature of this unique case.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Female
  • Humans
  • Killer Cells, Natural / immunology*
  • Lymphoma, Non-Hodgkin / immunology*
  • Phenotype
  • T-Lymphocytes