TNFAIP2 as an emerging therapeutic target in cancer therapy and its underlying mechanisms

Zhanqi Fu; Yuan Yuan

doi:10.1016/j.phrs.2024.107199

TNFAIP2 as an emerging therapeutic target in cancer therapy and its underlying mechanisms

Pharmacol Res. 2024 Apr 28:204:107199. doi: 10.1016/j.phrs.2024.107199. Online ahead of print.

Authors

Zhanqi Fu¹, Yuan Yuan²

Affiliations

¹ Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, the First Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, the First Hospital of China Medical University, Shenyang 110001, China.
² Tumor Etiology and Screening Department of Cancer Institute and General Surgery, the First Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, the First Hospital of China Medical University, Shenyang 110001, China; Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, the First Hospital of China Medical University, Shenyang 110001, China. Electronic address: yuanyuan@cmu.edu.cn.

PMID: 38688431
DOI: 10.1016/j.phrs.2024.107199

Abstract

TNFα-induced protein 2 (TNFAIP2), upregulated under TNFα stimulation, was initially thought to participate in angiogenesis. Still, more and more studies have found that TNFAIP2 plays multiple roles in various physiological and pathological scenarios. The representative functions of TNFAIP2 include motivating the inflammatory response, promoting angiogenesis, facilitating cell proliferation, adhesion, migration, and inducing tunnel nanotube formation. The expression of TNFAIP2 is abnormal in most cancers and can enhance drug resistance in cancer cells. The increasingly recognized significance of TNFAIP2 has been attracting growing attention in recent years. This review focuses on elucidating the relationship between TNFAIP2 and oncogenesis, as well as the latest research advancements in the pharmacological targeting of TNFAIP2, aiming to guide forthcoming endeavors in developing pharmacological agents targeted at modulating TNFAIP2.

Keywords: Cancer; Drug therapy; Nanotube formation; Pharmacology; TNFAIP2.

Publication types

Review