J Immunol. 1979 Nov;123(5):2161-7.

Mobility and density of AgB, "Ia", and Fc receptors on the surface of lymphocytes from young and old rats.

Abstract

Analysis of spleen cell populations from old Lewis rats (greater than 24 months) and from young Lewis rats (3 to 4 months) in a fluorescence-activated cell sorter indicated that with aging there is a loss of brightly stained Ia and Fc receptor- (FcR) positive cells. The density of AgB, Ia, and FcR was diminished on the surface of cells from old rats. The rate of capping of all three membrane proteins was slower on cells from old rats. Colchicine treatment allows capping of AgB with a single ligand only in young rats. Fluorescence photobleach recovery experiments (FPR) show that the fluidity of the lymphocyte membrane from old rats is diminished and the lateral diffusion of AgB is decreased. The colchicine and FPR experiments suggest that the changes in capping in old rats are due to, in part, alterations in membrane fluidity and cytoskeletal function.

PMID:: 385777; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging. [J Exp Med. 1979]
Density of surface immunoglobulin and capping on rat B lymphocytes. I. Changes with aging.
Woda BA, Feldman JD. J Exp Med. 1979 Feb 1; 149(2):416-23.
T lymphocytes of young and aged rats. I. Distribution, density, and capping of T antigens. [J Immunol. 1981]
T lymphocytes of young and aged rats. I. Distribution, density, and capping of T antigens.
Gilman SC, Woda BA, Feldman JD. J Immunol. 1981 Jul; 127(1):149-53.
Ligand-induced association of rat lymphocyte membrane proteins with the detergent-insoluble lymphocyte cytoskeletal matrix. [J Immunol. 1983]
Ligand-induced association of rat lymphocyte membrane proteins with the detergent-insoluble lymphocyte cytoskeletal matrix.
Woda BA, McFadden ML. J Immunol. 1983 Oct; 131(4):1917-9.
Review FcR-mediated inhibition of cell activation and other forms of coinhibition. [Crit Rev Immunol. 1998]
Review FcR-mediated inhibition of cell activation and other forms of coinhibition.
Anderson CC, Sinclair NR. Crit Rev Immunol. 1998; 18(6):525-44.
Review B lymphocyte biology studied with anti-Ig antibodies. [Immunol Rev. 1980]
Review B lymphocyte biology studied with anti-Ig antibodies.
Braun J, Unanue ER. Immunol Rev. 1980; 52:3-28.

See reviews... See all...

Cited by 4 PubMed Central articles

Mobility of surface proteins on normal rat macrophages and on a "macrophagelike" rat tumor. [J Cell Biol. 1981]
Mobility of surface proteins on normal rat macrophages and on a "macrophagelike" rat tumor.
Woda BA, Yguerabide J, Feldman JD. J Cell Biol. 1981 Sep; 90(3):705-10.
Elimination of syngeneic sarcomas in rats by a subset of T lymphocytes. [J Exp Med. 1980]
Elimination of syngeneic sarcomas in rats by a subset of T lymphocytes.
Fernandez-Cruz E, Woda BA, Feldman JD. J Exp Med. 1980 Oct 1; 152(4):823-41.
Immunoregulation in senescence: increased inducibility of antigen-specific suppressor T cells and loss of cell sensitivity to immunosuppression in aging mice. [Proc Natl Acad Sci U S A. 1982]
Immunoregulation in senescence: increased inducibility of antigen-specific suppressor T cells and loss of cell sensitivity to immunosuppression in aging mice.
Doria G, Mancini C, Adorini L. Proc Natl Acad Sci U S A. 1982 Jun; 79(12):3803-7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Mobility and density of AgB, "Ia", and Fc receptors on the surface of lymphocyte...
Mobility and density of AgB, "Ia", and Fc receptors on the surface of lymphocytes from young and old rats.
J Immunol. 1979 Nov ;123(5):2161-7.

PubMed
The Modified Hamilton Rating Scale for Depression: reliability and validity.
The Modified Hamilton Rating Scale for Depression: reliability and validity.
Psychiatry Res. 1985 Feb ;14(2):131-42.

PubMed
Purification and characterization of two cartilage-inducing factors from bovine ...
Purification and characterization of two cartilage-inducing factors from bovine demineralized bone.
Proc Natl Acad Sci U S A. 1985 Apr ;82(8):2267-71.

PubMed
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a review of cur...
Congenital adrenal hyperplasia due to 21-hydroxylase deficiency: a review of current knowledge.
J Endocrinol Invest. 1979 Jan-Mar ;2(1):93-100.

PubMed
Dieting and binging. A causal analysis.
Dieting and binging. A causal analysis.
Am Psychol. 1985 Feb ;40(2):193-201.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Mobility and density of AgB, "Ia", and Fc receptors on the surface of lymphocytes from young and old rats.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 4 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information