Identification and characterization of the human t...[Proc Natl Acad Sci U S A. 1985]

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1: Proc Natl Acad Sci U S A. 1985 May;82(9):2555-9. Links

Identification and characterization of the human type II collagen gene (COL2A1).

Cheah KS, Stoker NG, Griffin JR, Grosveld FG, Solomon E.

The gene contained in the human cosmid clone CosHcol1, previously designated an alpha 1(I) collagen-like gene, has now been identified. CosHcol1 hybridizes strongly to a single 5.9-kilobase mRNA species present only in tissue in which type II collagen is expressed. DNA sequence analysis shows that this clone is highly homologous to the chicken alpha 1(II) collagen gene. These data together suggest that CosHcol1 contains the human alpha 1(II) collagen gene COL2A1. The clone appears to contain the whole gene (30 kilobases in length) and will be extremely useful in the study of cartilage development and for identifying those inherited chondrodystrophies in which defects occur in this gene.

PMID: 3857598 [PubMed - indexed for MEDLINE]

PMCID: PMC397602

Isolation and characterization of overlapping genomic clones covering the chicken alpha 2 (type I) collagen gene.
Proc Natl Acad Sci U S A. 1980 Dec; 77(12):7059-63.

[Proc Natl Acad Sci U S A. 1980]
Structure of the type II collagen gene.
Ann N Y Acad Sci. 1985; 460:130-40.

[Ann N Y Acad Sci. 1985]
Molecular cloning of rat and human type IX collagen cDNA and localization of the alpha 1(IX) gene on the human chromosome 6.
Eur J Biochem. 1989 Jan 15; 179(1):71-8.

[Eur J Biochem. 1989]
Isolation and characterization of a genomic clone encoding chick alpha 1 type III collagen.
J Biol Chem. 1983 Mar 10; 258(5):2758-61.

[J Biol Chem. 1983]
ReviewTissue-specific expression of type IX collagen.
Ann N Y Acad Sci. 1990; 580:112-9.

[Ann N Y Acad Sci. 1990]
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Buttle DJ, Bramwell H, Hollander AP. Clin Mol Pathol. 1995 Aug; 48(4):M167-M177.

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Distinct gene expression profiles in different B-cell compartments in human peripheral lymphoid organs.
Shen Y, Iqbal J, Xiao L, Lynch RC, Rosenwald A, Staudt LM, Sherman S, Dybkaer K, Zhou G, Eudy JD, et al. BMC Immunol. 2004 Sep 15; 5:20. Epub 2004 Sep 15.

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IRF-7, a new interferon regulatory factor associated with Epstein-Barr virus latency.
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Identification and characterization of the human type II collagen gene (COL2A1).

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