Abstract
Pretreatment of mice genetically susceptible to type II collagen-induced arthritis (CIA) with monoclonal or polyclonal antisera specific for I region gene products (Ia antigens) suppressed or delayed the onset of CIA, whereas pretreatment with anti-Ia to an irrelevant haplotype was without effect. The humoral response to type II collagen was transiently depressed 14 days after immunization but antibody levels did not differ significantly after 28 days. The peak delayed-type hypersensitivity to type II collagen was unaffected by anti-Ia treatment. Monoclonal antibody of one anti-Ia specificity enhanced both the antibody response and the arthritis incidence in one mouse strain.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antibodies, Monoclonal / therapeutic use*
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Arthritis / therapy*
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Arthritis, Experimental / etiology
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Arthritis, Experimental / immunology
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Arthritis, Experimental / therapy*
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Autoantibodies / biosynthesis
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Cattle
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Chickens
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Collagen* / immunology
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Histocompatibility Antigens Class II / immunology*
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Hypersensitivity, Delayed / immunology
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Immunization, Passive
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Immunosuppressive Agents / therapeutic use*
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Kinetics
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Mice
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Mice, Inbred A
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Mice, Inbred C3H
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Prognosis
Substances
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Antibodies, Monoclonal
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Autoantibodies
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Histocompatibility Antigens Class II
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Immunosuppressive Agents
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Collagen