Abstract
Forty-one cases of dermatofibrosarcoma protuberans are presented. The clinical features and histopathological appearances are described. Immunohistochemical staining of thirteen cases with antisera to lysozyme, alpha 1-antichymotrypsin and S-100 protein has provided no evidence to support either a histiocytic or neuroectodermal origin for these tumours. In reviewing the literature, the histogenetic origin, differential diagnosis and malignant potential of dermatofibrosarcoma protuberans are discussed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Aged
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Chymotrypsin / antagonists & inhibitors
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Chymotrypsin / metabolism
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Female
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Fibrosarcoma / immunology
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Fibrosarcoma / pathology*
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Fibrosarcoma / physiopathology
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Humans
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Male
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Middle Aged
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Muramidase / metabolism
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S100 Proteins / metabolism
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Skin Neoplasms / immunology
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Skin Neoplasms / pathology*
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Skin Neoplasms / physiopathology
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alpha 1-Antichymotrypsin
Substances
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S100 Proteins
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alpha 1-Antichymotrypsin
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Muramidase
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Chymotrypsin