Dermatofibrosarcoma protuberans: a clinicopathological and immunohistochemical study with a review of the literature

Histopathology. 1985 Sep;9(9):921-38. doi: 10.1111/j.1365-2559.1985.tb02878.x.

Abstract

Forty-one cases of dermatofibrosarcoma protuberans are presented. The clinical features and histopathological appearances are described. Immunohistochemical staining of thirteen cases with antisera to lysozyme, alpha 1-antichymotrypsin and S-100 protein has provided no evidence to support either a histiocytic or neuroectodermal origin for these tumours. In reviewing the literature, the histogenetic origin, differential diagnosis and malignant potential of dermatofibrosarcoma protuberans are discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Chymotrypsin / antagonists & inhibitors
  • Chymotrypsin / metabolism
  • Female
  • Fibrosarcoma / immunology
  • Fibrosarcoma / pathology*
  • Fibrosarcoma / physiopathology
  • Humans
  • Male
  • Middle Aged
  • Muramidase / metabolism
  • S100 Proteins / metabolism
  • Skin Neoplasms / immunology
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / physiopathology
  • alpha 1-Antichymotrypsin

Substances

  • S100 Proteins
  • alpha 1-Antichymotrypsin
  • Muramidase
  • Chymotrypsin