Am J Hematol. 1985 Jun;19(2):195-200.

Hb Regina or alpha 2 beta 2 96(FG3)Leu----Val: a high oxygen affinity variant discovered by cation-exchange HPLC.

Abstract

Results are reported of studies of the hemoglobin from one member of a Canadian family with a mild erythrocytosis. This variant, which accounted for about 40% of the hemoglobin, could be separated from Hb A and Hb A2 by cation-exchange chromatography. Micro methodology allowed the characterization of a Leu----Val replacement at position beta 96(FG3). Hb Regina has an increased oxygen affinity, which adequately explains the hematological observations.

PMID:: 3839106; [PubMed - indexed for MEDLINE]

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Hb Regina or alpha 2 beta 2 96(FG3)Leu----Val: a high oxygen affinity variant di...
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