Objective: To study the correlation between the number of hemophagocytes and peripheral blood cells in bone marrow of patients with fever of unknown origin.
Methods: A total of 465 patients with fever of unknown origin in our hospital from January 2019 to December 2021 were selected as the research objects, which was to reviewed retrospectively the correlation between the number of hemophagocytes and peripheral blood cells in bone marrow.
Results: The positive rates of hemophagocytes detected in the three lines decreased group, the two lines decreased group, the one line decreased group, normal group of the three lines and at least one of the three lines increased group were 86.4%, 62.1%, 38.3%, 34.6% and 33.3%, respectively. The number of hemophagocytes per unit area in the three lines decreased group was significantly higher than that in the other four groups ( P < 0.001). The number of hemophagocytes per unit area in the two lines decreased group was higher than that in the one line decreased group, normal group of three lines and at least one of the three lines increased group ( P < 0.01). There was no significant difference in the number of hemophagocytes per unit area between the group with a decreased number of one line and the other two groups with a normal number of three lines and the group with at least one increased number of three lines (P >0.05). The missed rates of hemophagocytes in the five groups were 15.78%, 22.03%, 62.22%, 77.78% and 53.84%, respectively.
Conclusion: For patients with fever of unknown origin, especially those with obvious decrease in the number of three lines and two lines in peripheral blood cells, which should pay attention to the detection of hemophagocytes in bone marrow. Meanwhile, if the number of three lines was normal even at least one of the three lines increased, the presence of hemophagocytes in the bone marrow slice should be also carefully observed.
题目: 骨髓中噬血细胞数量与外周血细胞数量的相关性分析.
目的: 研究不明原因发热患者骨髓中噬血细胞数量与外周血细胞数量的相关性。.
方法: 选取2019年1月至2021年12月本院收治的不明原因发热患者465例作为研究对象，回顾性分析其骨髓噬血细胞数量与外周血三系细胞数量的相关性。.
结果: 三系数量减少、两系数量减少、一系数量减少、三系数量正常以及三系正常至少一系升高组检出噬血细胞的阳性率分别为86.4%、62.1%、38.3%、34.6%及33.3%。其中三系数量减少组与其它4组相比，单位面积噬血细胞数明显升高（P < 0.001）；两系数量减少组单位面积噬血细胞数高于一系数量减少组、三系数量正常组、三系正常至少一系升高组（P <0.01）；一系数量减少组与三系数量正常组、三系正常至少一系升高组，三系数量正常组与三系正常至少一系升高组相比，单位面积噬血细胞数差异均无统计学意义（P >0.05）。5组的噬血细胞漏检率分别为15.78%、22.03%、62.22%、77.78%及53.84%。.
结论: 对于不明原因发热患者尤其是外周血三系及两系细胞数量明显减少者要格外注意骨髓中噬血细胞的检出，同时对于三系细胞数量正常甚至至少有一系升高者也应仔细观察髓片中是否有噬血细胞的存在。.
Keywords: fever; bone marrow cytology; hemophagocytes; missing rate.