A solid-state NMR method for characterization of pharmaceutical eutectics

Phys Chem Chem Phys. 2024 Jan 31;26(5):3800-3803. doi: 10.1039/d3cp05615e.

Abstract

Pharmaceutical eutectics are extremely useful for designing formulations, and currently, there are no techniques other than differential scanning calorimetry (DSC) that can confirm their formation. In this study, we demonstrate that 1H fast magic angle spinning (MAS) solid-state NMR (SSNMR) experiments can confirm the formation of eutectics by detecting their intermolecular hydrogen bonding interactions.

MeSH terms

  • Drug Compounding
  • Magnetic Resonance Imaging*
  • Magnetic Resonance Spectroscopy / methods
  • Pharmaceutical Preparations

Substances

  • Pharmaceutical Preparations