Heart development protein with EGF-like domains 1 (HEG1) is a novel mucin-like membrane protein with a long O-glycosylation region and EGF domain. HEG1 plays critical roles in embryo development and cardiogenesis, and is closely related to the occurrence and progression of malignant tumors. Here this article demonstrates the research progress on HEG1 in cardiovascular formation and tumor development in recent years, to inspire new ideas for the pathogenesis, diagnosis and treatment of related diseases.
具有表皮生长因子样结构域的心脏发育蛋白1（heart development protein with EGF-like domains 1，HEG1）是一种新型的黏蛋白样膜蛋白，具有较长的O-糖基化区域和EGF结构域。近年来研究发现，HEG1在胚胎发育和心血管生成中起关键作用，也与一系列肿瘤的发生发展密切相关。本文介绍HEG1在心血管形成和肿瘤发生发展中的研究进展，为相关疾病的发病机制和诊疗提供思路。.