Neurosci Lett. 1987 Jan 14;73(2):192-6.

A disorder of cortical GABAergic innervation in Alzheimer's disease.

Hardy J, Cowburn R, Barton A, Reynolds G, Dodd P, Wester P, O'Carroll AM, Lofdahl E, Winblad B.

Abstract

Synaptosomal gamma-aminobutyric acid (GABA) uptake has been used as a biochemical marker for GABAergic terminals in controls and Alzheimer disease brains. Use of this marker suggests a large (ca. 70%) loss of cortical and hippocampal GABA terminals in Alzheimer brain. To explain this observation we suggest that neuron loss in this disorder occurs via a process of cortical retrograde degeneration. This scheme reconciles our findings with previous neurochemical measurements on Alzheimer disease brains and also better reconciles the biochemistry with the histology of the disorder.

PMID:: 3822251; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

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gamma-Aminobutyric Acid

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Alzheimer's Disease - MedlinePlus Health Information

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