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Nature. 1979 Sep 13;281(5727):122-5.

A structurally abnormal insulin causing human diabetes.

Abstract

Insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinaemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation. Chemical studies suggest that the isolated hormone is a mixture of normal insulin and an abnormal variant which contains a leucine for phenylalanine substitution at position 24 or 25 of the insulin B-chain.

PMID:
381941
[PubMed - indexed for MEDLINE]
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