Patient acceptability of, and attitudes towards, hepatitis B cure research - A scoping review and identification of knowledge gaps

Neaka Mohtashemi; Karine Dubé; Chloe Thio; Sihyeong Song; Shail Patel; Jeremy Sugarman; Debika Bhattacharya

doi:10.1016/j.jve.2023.100354

Patient acceptability of, and attitudes towards, hepatitis B cure research - A scoping review and identification of knowledge gaps

J Virus Erad. 2023 Nov 24;9(4):100354. doi: 10.1016/j.jve.2023.100354. eCollection 2023 Dec.

Authors

Neaka Mohtashemi¹, Karine Dubé², Chloe Thio³, Sihyeong Song¹, Shail Patel¹, Jeremy Sugarman³, Debika Bhattacharya¹

Affiliations

¹ University of California, Los Angeles, Los Angeles, CA, USA.
² University of California, San Diego, San Diego, CA, USA.
³ Johns Hopkins University, Baltimore, MD, USA.

Abstract

Functional cure, defined as durable loss of hepatitis B surface antigen (HBsAg) and hepatitis B virus (HBV) DNA suppression off therapy, is an increasingly important goal in the treatment of chronic hepatitis B. Although novel treatments aimed at achieving functional cure are being developed and tested in clinical trials, it is important to assess the perspectives of people living with HBV towards these potential treatments and their participation in HBV functional cure research. We have performed a scoping review that revealed that there is limited knowledge regarding patient perspectives of HBV functional cure research and then identified gaps in knowledge for further investigation. Our work highlights the need for further studies in patient perspectives in HBV functional cure research.

Keywords: Clinical trials; Functional cure; HBV.

Publication types

Review