Alcohol. 1986 Nov-Dec;3(6):367-70.

1,4-Butanediol and ethanol compete for degradation in rat brain and liver in vitro.

Abstract

We examined the enzymatic reaction responsible for the conversion of 1,4 butanediol to gamma-hydroxybutyric acid and the interaction of ethanol with this conversion in brain and liver. The enzyme responsible for this reaction in liver appears to be alcohol dehydrogenase. However, in both tissues, there was a competitive inhibition by ethanol of the conversion of 1,4 butanediol to gamma-hydroxybutyric acid with an apparent Ki of 6.5 X 10(-3) M in brain and 2.7 X 10(-3) M in liver. These findings may explain the potentiation of the behavioral effects of ethanol by 1,4 butanediol.

PMID:: 3814347; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Molecular Biology Databases

Supplemental Content

Related citations

1,4 Butanediol, gamma-hydroxybutyric acid and ethanol: relationships and interactions. [Neuropharmacology. 1984]
1,4 Butanediol, gamma-hydroxybutyric acid and ethanol: relationships and interactions.
Poldrugo F, Snead OC 3rd. Neuropharmacology. 1984 Jan; 23(1):109-113.
In vivo conversion of gamma-aminobutyric acid and 1,4-butanediol to gamma-hydroxybutyric acid in rat brain. Studies using stable isotopes. [Biochem Pharmacol. 1989]
In vivo conversion of gamma-aminobutyric acid and 1,4-butanediol to gamma-hydroxybutyric acid in rat brain. Studies using stable isotopes.
Snead OC 3rd, Furner R, Liu CC. Biochem Pharmacol. 1989 Dec 15; 38(24):4375-80.
Identification and quantitation of 1,4-butanediol in mammalian tissues: an alternative biosynthetic pathway for gamma-hydroxybutyric acid. [Biochem Pharmacol. 1985]
Identification and quantitation of 1,4-butanediol in mammalian tissues: an alternative biosynthetic pathway for gamma-hydroxybutyric acid.
Barker SA, Snead OC, Poldrugo F, Liu CC, Fish FP, Settine RL. Biochem Pharmacol. 1985 May 15; 34(10):1849-52.
Review NTP summary report on the metabolism, disposition, and toxicity of 1,4-butanediol (CAS No. 110-63-4). [Toxic Rep Ser. 1996]
Review NTP summary report on the metabolism, disposition, and toxicity of 1,4-butanediol (CAS No. 110-63-4).
Irwin RD. Toxic Rep Ser. 1996 May; (54):1-28, A1-8, B1-5.
Review A review of evidence leading to the prediction that 1,4-butanediol is not a carcinogen. [J Appl Toxicol. 2006]
Review A review of evidence leading to the prediction that 1,4-butanediol is not a carcinogen.
Irwin RD. J Appl Toxicol. 2006 Jan-Feb; 26(1):72-80.

See reviews... See all...

Cited by 2 PubMed Central articles

Cardiovascular responses elicited by intragastric administration of BDL and GHB. [J Recept Signal Transduct Res. 2008]
Cardiovascular responses elicited by intragastric administration of BDL and GHB.
Hicks AR, Varner KJ. J Recept Signal Transduct Res. 2008; 28(4):429-36.
Pharmacokinetics of 1,4-butanediol in rats: bioactivation to gamma-hydroxybutyric acid, interaction with ethanol, and oral bioavailability. [AAPS J. 2008]
Pharmacokinetics of 1,4-butanediol in rats: bioactivation to gamma-hydroxybutyric acid, interaction with ethanol, and oral bioavailability.
Fung HL, Tsou PS, Bulitta JB, Tran DC, Page NA, Soda D, Mi Fung S. AAPS J. 2008; 10(1):56-69. Epub 2008 Feb 8.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

1,4-Butanediol and ethanol compete for degradation in rat brain and liver in vit...
1,4-Butanediol and ethanol compete for degradation in rat brain and liver in vitro.
Alcohol. 1986 Nov-Dec ;3(6):367-70.

PubMed
Human vaginal leukocytes and the effects of vaginal fluid on lymphocyte and macr...
Human vaginal leukocytes and the effects of vaginal fluid on lymphocyte and macrophage defense functions.
Am J Obstet Gynecol. 1992 Feb ;166(2):720-6.

PubMed
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central ner...
Disruption of the Cbfa2 gene causes necrosis and hemorrhaging in the central nervous system and blocks definitive hematopoiesis.
Proc Natl Acad Sci U S A. 1996 Apr 16 ;93(8):3444-9.

PubMed
Significance of postnatal mother-to-child transmission of human T-lymphotropic v...
Significance of postnatal mother-to-child transmission of human T-lymphotropic virus type-I on the development of adult T-cell leukemia/lymphoma.
J Med Virol. 1986 Nov ;20(3):253-60.

PubMed
The prevalence of anencephalus and spina bifida in New Zealand.
The prevalence of anencephalus and spina bifida in New Zealand.
J Paediatr Child Health. 1993 Aug ;29(4):282-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to:

1,4-Butanediol and ethanol compete for degradation in rat brain and liver in vitro.

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Molecular Biology Databases

Supplemental Content

Related citations

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information