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The gene for human chromogranin A (CgA) is located on chromosome 14.
Chromogranin A (CgA) is a protein that is present in most neuroendocrine tissues and is co-secreted with their resident hormones. We have assigned the CgA gene to human chromosome 14 by hybridization of a CgA cDNA probe cloned from a cDNA library of human medullary thyroid carcinoma cells to spots of individual human chromosomes flow-sorted onto nitrocellulose filters. Southern analysis of human genomic DNA with the same probe revealed only 1-3 restriction bands. These studies indicate that the CgA gene is probably single copy and not a member of a dispersed, multigene family. The CgA gene is not co-localized with the genes of any of the CgA-associated hormones.
PMID: 3814131 [PubMed - indexed for MEDLINE]
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Cited by 6 PubMed Central articles
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Cell type-specific gene expression in the neuroendocrine system. A neuroendocrine-specific regulatory element in the promoter of chromogranin A, a ubiquitous secretory granule core protein.
Wu H, Rozansky DJ, Webster NJ, O'Connor DT.
J Clin Invest. 1994 Jul; 94(1):118-29.
[J Clin Invest. 1994]
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Chromogranin positive cells in colorectal carcinoma and transitional mucosa.
Mori M, Mimori K, Kamakura T, Adachi Y, Ikeda Y, Sugimachi K.
J Clin Pathol. 1995 Aug; 48(8):754-8.
[J Clin Pathol. 1995]
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Secretion from chromaffin cells is controlled by chromogranin A-derived peptides.
Simon JP, Bader MF, Aunis D.
Proc Natl Acad Sci U S A. 1988 Mar; 85(5):1712-6.
[Proc Natl Acad Sci U S A. 1988]
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