Arch Neurol. 1987 Feb;44(2):225-7.

Adult metachromatic leukodystrophy. Value of computed tomographic scanning and magnetic resonance imaging of the brain.

Abstract

Patients with adult-onset metachromatic leukodystrophy (MLD) often present with personality changes or deterioration of cognitive functions. Although rare, this form of MLD should be included in the differential diagnosis of psychotic and dementing disorders. The following case report describes a 38-year-old man with adult-onset MLD, who carried the diagnosis of schizophrenia and was treated as a schizophrenic for a number of years. Metachromatic leukodystrophy was initially suspected because of white matter abnormalities detected on computed tomographic scans and magnetic resonance images of the brain. The diagnosis of MLD was confirmed by the discovery of markedly reduced leukocyte arylsulfatase A activity. The computed tomographic and magnetic resonance imaging findings in MLD are reviewed.

PMID:: 3813937; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms

Publication Types

Case Reports

MeSH Terms

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Icon for Silverchair Information Systems

Save items

Related citations in PubMed

CT and MRI in late-onset metachromatic leukodystrophy. [Acta Neurol Scand. 1987]
CT and MRI in late-onset metachromatic leukodystrophy.
Reider-Grosswasser I, Bornstein N. Acta Neurol Scand. 1987 Jan; 75(1):64-9.
[Metachromatic leukodystrophy simulating schizophrenia-like psychosis]. [Nervenarzt. 1997]
[Metachromatic leukodystrophy simulating schizophrenia-like psychosis].
Hermle L, Becker FW, Egan PJ, Kolb G, Wesiack B, Spitzer M. Nervenarzt. 1997 Sep; 68(9):754-8.
Metachromatic leukodystrophy (MLD). XV. Adult MLD with focal lesions by computed tomography. [Arch Neurol. 1983]
Metachromatic leukodystrophy (MLD). XV. Adult MLD with focal lesions by computed tomography.
Skomer C, Stears J, Austin J. Arch Neurol. 1983 Jun; 40(6):354-5.
Review [2 familial cases of metachromatic leukodystrophy of late onset]. [Rev Neurol (Paris). 1997]
Review [2 familial cases of metachromatic leukodystrophy of late onset].
Brault JL, Gielselmann V, Carpentier A, Lefèvre M, Turpin JC, Baumann N. Rev Neurol (Paris). 1997 Apr; 153(3):193-6.
Review Psychiatric disturbances in metachromatic leukodystrophy. Insights into the neurobiology of psychosis. [Arch Neurol. 1992]
Review Psychiatric disturbances in metachromatic leukodystrophy. Insights into the neurobiology of psychosis.
Hyde TM, Ziegler JC, Weinberger DR. Arch Neurol. 1992 Apr; 49(4):401-6.

See reviews... See all...

Cited by 2 PubMed Central articles

Adult metachromatic leucodystrophy: an underdiagnosed disease? [J Neurol Neurosurg Psychiatry....]
Adult metachromatic leucodystrophy: an underdiagnosed disease?
Cerizza M, Nemni R, Tamma F. J Neurol Neurosurg Psychiatry. 1987 Dec; 50(12):1710-2.
Adult metachromatic leukodystrophy with an unusual relapsing-remitting course. [Postgrad Med J. 1992]
Adult metachromatic leukodystrophy with an unusual relapsing-remitting course.
Sadeh M, Kuritzky A, Ben-David E, Goldhammer Y. Postgrad Med J. 1992 Mar; 68(797):192-5.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Adult metachromatic leukodystrophy. Value of computed tomographic scanning and m...
Adult metachromatic leukodystrophy. Value of computed tomographic scanning and magnetic resonance imaging of the brain.
Arch Neurol. 1987 Feb ;44(2):225-7.

PubMed
Recognition of alcoholism and substance abuse in primary care patients.
Recognition of alcoholism and substance abuse in primary care patients.
Arch Intern Med. 1987 Feb ;147(2):349-52.

PubMed
Magnetic resonance imaging of the midbrain in Parkinson's disease.
Magnetic resonance imaging of the midbrain in Parkinson's disease.
Ann Neurol. 1986 Dec ;20(6):744-7.

PubMed
The advantages of studying psychological phenomena rather than psychiatric diagn...
The advantages of studying psychological phenomena rather than psychiatric diagnoses.
Am Psychol. 1986 Nov ;41(11):1252-60.

PubMed
Enzymatic synthesis of uridine diphosphate N-acetyl-D-mannosaminuronic acid.
Enzymatic synthesis of uridine diphosphate N-acetyl-D-mannosaminuronic acid.
J Biol Chem. 1979 Sep 10 ;254(17):8457-65.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: