An autoantibody with potent antithrombin activity ...[Am J Hematol. 1987]

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1: Am J Hematol. 1987 Feb;24(2):207-14.Links

An autoantibody with potent antithrombin activity whose action could be inhibited by toluidine blue or methylene blue.

Shojania AM, Meilleur G, Alvi AW.

A 41-year-old man with posthepatic liver cirrhosis and bleeding tendency was found to have a circulating anticoagulant with potent antithrombin activity. The thrombin time of the patient's purified fibrinogen was normal. This anticoagulant was residing in the patient's IgG fraction, and his IgG fraction could prolong the thrombin time of purified fibrinogen, suggesting that this circulating anticoagulant was an antibody. No heparin was detected in the patient's plasma. However, the antithrombin activity of this anticoagulant could be neutralized by toluidine blue or methylene blue ex vivo.

PMID: 3812468 [PubMed - indexed for MEDLINE]

The effect of toluidine blue and methylene blue in immunochemical reactions in vitro.
Clin Immunol Immunopathol. 1987 May; 43(2):223-8.

[Clin Immunol Immunopathol. 1987]
Simultaneous occurrence of human antibodies directed against fibrinogen, thrombin, and factor V following exposure to bovine thrombin: effects on blood coagulation, protein C activation and platelet function.
Thromb Haemost. 1997 Feb; 77(2):343-9.

[Thromb Haemost. 1997]
An acquired inhibitor that produced a delay of fibrinopeptide B release in an asymptomatic patient.
Haematologica. 2007 Feb; 92(2):e17-9.

[Haematologica. 2007]
ReviewTransient hemorrhagic diathesis associated with an inhibitor of prothrombin with lupus anticoagulant in a 1 1/2-year-old girl: report of a case and review of the literature.
Am J Hematol. 1996 Apr; 51(4):307-14.

[Am J Hematol. 1996]
Review[Unexpectedly prolonged thrombin time]
Schweiz Med Wochenschr. 1993 Mar 27; 123(12):523-9.

[Schweiz Med Wochenschr. 1993]
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