The Bilateral Carotid Artery Stenosis (BCAS) Model of Vascular Dementia

Quynh Nhu Dinh; Thiruma Arumugam

doi:10.1007/978-1-0716-3585-8_5

The Bilateral Carotid Artery Stenosis (BCAS) Model of Vascular Dementia

Methods Mol Biol. 2024:2746:67-72. doi: 10.1007/978-1-0716-3585-8_5.

Authors

Quynh Nhu Dinh¹, Thiruma Arumugam²

Affiliations

¹ Department of Microbiology, Anatomy, Physiology and Pharmacology, Centre for Cardiovascular Biology and Disease Research, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, Australia. q.dinh@latrobe.edu.au.
² Department of Microbiology, Anatomy, Physiology and Pharmacology, Centre for Cardiovascular Biology and Disease Research, School of Agriculture, Biomedicine and Environment, La Trobe University, Bundoora, VIC, Australia.

PMID: 38070080
DOI: 10.1007/978-1-0716-3585-8_5

Abstract

Vascular dementia is the second most common form of dementia after Alzheimer's disease. Chronic cerebral hypoperfusion is a key contributor to the development of vascular dementia. In this chapter, we describe the surgical procedures used for bilateral carotid artery stenosis (BCAS) surgery to induce chronic cerebral hypoperfusion. Mice that undergo BCAS surgery develop the hallmarks of vascular dementia including white matter lesions, neuroinflammation, and cognitive impairment. This technique may be used for studies of chronic cerebral hypoperfusion and vascular dementia in mice.

Keywords: Brain; Carotid arteries; Cerebral blood flow; Chronic cerebral hypoperfusion; Vascular dementia.

MeSH terms

Animals
Brain Ischemia*
Carotid Stenosis* / complications
Carotid Stenosis* / pathology
Carotid Stenosis* / psychology
Cognitive Dysfunction*
Dementia, Vascular* / etiology
Dementia, Vascular* / pathology
Disease Models, Animal
Mice
Mice, Inbred C57BL