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Association of lipid-laden alveolar macrophages and gastroesophageal reflux in children.
The association of lipid-laden alveolar macrophages (LLAM) and gastroesophageal reflux (GER) was investigated prospectively in 115 patients in two groups. Group 1 included 74 children with chronic respiratory tract disorders and documented GER by prolonged esophageal pH monitoring, barium esophagram, and esophagoscopy; group 2 included 41 children with chronic respiratory tract disorders without GER. LLAM were present in 63 (85%) and eight (19%) children from groups 1 and 2, respectively (P less than 0.0001). Thus a strong association between the presence of LLAM and GER in children with chronic respiratory tract disorders was established. We suggest that LLAM from bronchial lavage may be a useful marker for tracheal aspiration in children with GER in whom chronic lung disease may subsequently develop.
PMID: 3806289 [PubMed - indexed for MEDLINE]
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Cited by 2 PubMed Central articles
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Simultaneous tracheal and oesophageal pH monitoring during mechanical ventilation.
Hue V, Leclerc F, Gottrand F, Martinot A, Crunelle V, Riou Y, Deschildre A, Fourier C, Turck D.
Arch Dis Child. 1996 Jul; 75(1):46-50.
[Arch Dis Child. 1996]
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Does mechanical ventilation precipitate gastro-oesophageal reflux during enteral feeding?
Newell SJ, Morgan ME, Durbin GM, Booth IW, McNeish AS.
Arch Dis Child. 1989 Oct; 64(10 Spec No):1352-5.
[Arch Dis Child. 1989]