Exploring the role of aquaporin proteins in the pre-protective action of Sanwei sandalwood decoction from adriamycin-induced chronic heart failure: A mechanistic study

Surilige; Pengfei Hu; Tingting Bai; Zhi Xiu; Hujiya; Ming Li; Qingshan Zhang; Quan Wan

doi:10.1016/j.heliyon.2023.e22718

Exploring the role of aquaporin proteins in the pre-protective action of Sanwei sandalwood decoction from adriamycin-induced chronic heart failure: A mechanistic study

Heliyon. 2023 Nov 25;9(12):e22718. doi: 10.1016/j.heliyon.2023.e22718. eCollection 2023 Dec.

Authors

Surilige¹, Pengfei Hu¹, Tingting Bai², Zhi Xiu³, Hujiya³, Ming Li³, Qingshan Zhang¹, Quan Wan¹

Affiliations

¹ Affiliated Hospital of Inner Mongolia University for Nationalities Inner Mongolia, China.
² Key Laboratory of Mongolian Medicine Pharmacology for Cardio Inner Mongolia, China.
³ Clinical Medical College of Inner Mongolia University for Nationalities Inner Mongolia, China.

Abstract

This study employed network pharmacology, molecular docking technology, and modern pharmacological research methods to explore the pre-protective effect and underlying mechanism, Sanwei sandalwood decoction, against Adriamycin-induced Chronic Heart Failure, with a particular focus on the involvement of aquaporins. Additionally, the study highlighted aquaporins as a significant factor, affecting processes such as cell proliferation and response to reactive oxygen species. The results of in vivo experiments demonstrated that the administration of Sanwei sandalwood decoction in rats with chronic heart failure led to an enhancement in the ejection fraction and improved heart ejection function. Additionally, the decoction significantly reduced the serum levels of Creatine Kinase, Creatine Kinase-MB, and N-terminal pro-B-type natriuretic peptide. Furthermore, the relative expression of Aquarporin-1, 4, and 7mRNAs and proteins in the hearts of rats with chronic heart failure was down-regulated upon treatment. Overall, Sanwei sandalwood decoction can have an effective cardioprotective effect in preventing Adriamycin-induced Chronic Heart Failure in rats.

Keywords: Adriamycin-induced chronic heart failure; Aquaporin proteins; Molecular docking technology; Network pharmacology; Sanwei sandalwood decoction.