Fructose sweetens the adipocyte-T cell alliance against tumors

Peipei Zhou; Hongbo Chi

doi:10.1016/j.cmet.2023.11.004

Fructose sweetens the adipocyte-T cell alliance against tumors

Cell Metab. 2023 Dec 5;35(12):2093-2094. doi: 10.1016/j.cmet.2023.11.004.

Authors

Peipei Zhou¹, Hongbo Chi²

Affiliations

¹ Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
² Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address: hongbo.chi@stjude.org.

PMID: 38056424
DOI: 10.1016/j.cmet.2023.11.004

Abstract

Dietary fructose is implicated in tumorigenesis, but whether dietary fructose regulates antitumor immunity remains elusive. In this issue of Cell Metabolism, Zhang et al. show that dietary fructose promotes adipocyte-derived leptin production, which attenuates terminal exhaustion programming and boosts the effector function of CD8⁺ T cells for improved tumor control.

Publication types

Research Support, N.I.H., Extramural
Comment

MeSH terms

Adipocytes
CD8-Positive T-Lymphocytes*
Fructose / metabolism
Humans
Neoplasms* / metabolism

Substances

Fructose

Abstract

Publication types

MeSH terms

Substances

Grants and funding