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    Exp Gerontol. 1986;21(3):187-93.

    Age-related changes in rat liver plasma membrane phospholipase A2 activity.

    Petkova DH, Momchilova AB, Koumanov KS.

    Abstract

    The alterations of the lipid composition and fluidity of liver plasma membranes as well as the activity of membrane-bound phospholipase A2 (EC 3.1.1.4) in male and female rats of different ages are investigated. An age-induced increase of the protein/phospholipid and cholesterol/phospholipid ratios is observed, as well as a decrease in the unsaturation index of plasma membrane phosphatidylcholine. These changes induce an augmentation of the steady-state fluorescent anisotropy-rs and structural order parameter for 1,6-diphenyl-1,3,5-hexatriene-SDPH in plasma membranes. The membrane-bound phospholipase A2 activity is enhanced with aging, correlating well with the reduced membrane fluidity. The sex-determined alterations in all these parameters is also investigated.

    PMID:
    3803470
    [PubMed - indexed for MEDLINE]

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