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Antidepressant and circadian phase-shifting effects of light.
Bright light can suppress nighttime melatonin production in humans, but ordinary indoor light does not have this effect. This finding suggested that bright light may have other chronobiologic effects in humans as well. Eight patients who regularly became depressed in the winter (as day length shortens) significantly improved after 1 week of exposure to bright light in the morning (but not after 1 week of bright light in the evening). The antidepressant response to morning light was accompanied by an advance (shift to an earlier time) in the onset of nighttime melatonin production. These results suggest that timing may be critical for the antidepressant effects of bright light.
PMID: 3798117 [PubMed - indexed for MEDLINE]
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Cited by 13 PubMed Central articles
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ReviewCircadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine review.
Sack RL, Auckley D, Auger RR, Carskadon MA, Wright KP Jr, Vitiello MV, Zhdanova IV, American Academy of Sleep Medicine.
Sleep. 2007 Nov 1; 30(11):1460-83.
[Sleep. 2007]
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De novo discovery of serotonin N-acetyltransferase inhibitors.
Szewczuk LM, Saldanha SA, Ganguly S, Bowers EM, Javoroncov M, Karanam B, Culhane JC, Holbert MA, Klein DC, Abagyan R, et al.
J Med Chem. 2007 Nov 1; 50(22):5330-8. Epub 2007 Oct 9.
[J Med Chem. 2007]
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Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug.
Hwang Y, Ganguly S, Ho AK, Klein DC, Cole PA.
Bioorg Med Chem. 2007 Mar 1; 15(5):2147-55. Epub 2006 Dec 13.
[Bioorg Med Chem. 2007]
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