Visible-light-mediated synthesis of oxime esters via multicomponent reactions of aldehydes, aryl amines, and N-hydroxyphthalimide esters

Anh Thu Nguyen; Hee-Kwon Kim

doi:10.1039/d3ra06737h

Visible-light-mediated synthesis of oxime esters via multicomponent reactions of aldehydes, aryl amines, and N-hydroxyphthalimide esters

RSC Adv. 2023 Oct 26;13(45):31346-31352. doi: 10.1039/d3ra06737h.

Authors

Anh Thu Nguyen¹, Hee-Kwon Kim^{1

2}

Affiliations

¹ Department of Nuclear Medicine, Jeonbuk National University Medical School and Hospital Jeonju 54907 Republic of Korea hkkim717@jbnu.ac.kr.
² Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital Jeonju 54907 Republic of Korea.

Abstract

Oxime esters are useful scaffolds in many organic chemistry transformations. Herein, a novel visible-light-mediated three-component reaction for synthesis of oxime esters is reported. Aldehydes, aniline, and N-hydroxyphthalimide (NHPI) esters were used as substrates in this three-component reaction, and eosin Y was used as a crucial photocatalyst for the reaction. Wide ranges of aldehydes and NHPI esters were well tolerated in this reaction method, generating various oxime esters with high efficiency under mild reaction conditions. This visible-light-mediated methodology will be a promising approach to synthesize useful oxime esters in a single step.