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A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.
The alternative or classical pathways for complement system component C3 may be triggered by microorganisms and antigen-antibody complexes. In particular, an activated fragment of C3, C3b, covalently attaches to microorganisms or antigen-antibody complexes, which in turn bind to the C3b receptor, also known as complement receptor 1. The genes encoding the proteins that constitute the C3-activating enzymes have been cloned and mapped to a "complement activation" locus in the major histocompatibility complex, and we demonstrate in this study such a locus on the long arm of chromosome 1 at band 1q32.
PMID: 3782802 [PubMed - indexed for MEDLINE]
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Cited by 26 PubMed Central articles
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Clustering of missense mutations in the C-terminal region of factor H in atypical hemolytic uremic syndrome.
Pérez-Caballero D, González-Rubio C, Gallardo ME, Vera M, López-Trascasa M, Rodríguez de Córdoba S, Sánchez-Corral P.
Am J Hum Genet. 2001 Feb; 68(2):478-84. Epub 2001 Jan 17.
[Am J Hum Genet. 2001]
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Chromosomal location of the genes encoding the leukocyte adhesion receptors LFA-1, Mac-1 and p150,95. Identification of a gene cluster involved in cell adhesion.
Corbi AL, Larson RS, Kishimoto TK, Springer TA, Morton CC.
J Exp Med. 1988 May 1; 167(5):1597-607.
[J Exp Med. 1988]
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Molecular cloning and chromosomal localization of human membrane cofactor protein (MCP). Evidence for inclusion in the multigene family of complement-regulatory proteins.
Lublin DM, Liszewski MK, Post TW, Arce MA, Le Beau MM, Rebentisch MB, Lemons LS, Seya T, Atkinson JP.
J Exp Med. 1988 Jul 1; 168(1):181-94.
[J Exp Med. 1988]
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