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Amino acid sequence of human acidic fibroblast growth factor.
The complete amino acid sequence of human brain acidic fibroblast growth factor (aFGF) has been established. Human aFGF consists of 140 amino acids and is highly homologous to bovine aFGF (11 amino acid replacements). Results from experiments involving alkylation of cysteine residues are compatible with the possibilities that in aFGF all three cysteines exist as free sulfhydryls, or alternatively, that a disulfide bridge is present but cannot be identified due to disulfide scrambling caused by the SH group of the remaining cysteine. A potential glycosylation site Asn114-Gly115-Ser116 is present in aFGF but the mitogen does not bind to lectins suggesting that it may not be glycosylated.
PMID: 3778488 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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Endothelial cell growth factors in embryonic and adult chick brain are related to human acidic fibroblast growth factor.
Risau W, Gautschi-Sova P, Böhlen P.
EMBO J. 1988 Apr; 7(4):959-62.
[EMBO J. 1988]
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Cloning of the gene coding for human class 1 heparin-binding growth factor and its expression in fetal tissues.
Wang WP, Lehtoma K, Varban ML, Krishnan I, Chiu IM.
Mol Cell Biol. 1989 Jun; 9(6):2387-95.
[Mol Cell Biol. 1989]
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Detection of high levels of heparin binding growth factor-1 (acidic fibroblast growth factor) in inflammatory arthritic joints.
Sano H, Forough R, Maier JA, Case JP, Jackson A, Engleka K, Maciag T, Wilder RL.
J Cell Biol. 1990 Apr; 110(4):1417-26.
[J Cell Biol. 1990]