The skeletal muscle metaboreflex: a novel driver of ventilation, dyspnoea and pulmonary haemodynamics during exercise in pulmonary arterial hypertension

Michael J Plunkett; Ana Luiza C Sayegh; Tanya J McWilliams; Sasiharan Sithamparanathan; Julian F R Paton; James P Fisher

doi:10.1183/13993003.00952-2023

The skeletal muscle metaboreflex: a novel driver of ventilation, dyspnoea and pulmonary haemodynamics during exercise in pulmonary arterial hypertension

Eur Respir J. 2024 Jan 4;63(1):2300952. doi: 10.1183/13993003.00952-2023. Print 2024 Jan.

Authors

Michael J Plunkett^{1

2}, Ana Luiza C Sayegh¹, Tanya J McWilliams², Sasiharan Sithamparanathan², Julian F R Paton¹, James P Fisher³

Affiliations

¹ Manaaki Mānawa - The Centre for Heart Research, Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
² Respiratory Medicine, Te Toka Tumai Auckland, Te Whatu Ora Health New Zealand, Auckland, New Zealand.
³ Manaaki Mānawa - The Centre for Heart Research, Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand jp.fisher@auckland.ac.nz.

Abstract

During exercise, the skeletal muscle metaboreflex is enhanced in pulmonary arterial hypertension, and drives excess ventilation and increased pulmonary artery pressure, and increases the perception of dyspnoea https://bit.ly/3OG46f6

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Blood Pressure / physiology
Dyspnea
Heart Rate
Hemodynamics
Humans
Lung
Muscle, Skeletal
Pulmonary Arterial Hypertension*
Reflex