Am J Dermatopathol. 1986 Aug;8(4):314-20.

Penicillamine-induced elastosis perforans serpiginosa. Tip of the iceberg?

Abstract

Elastosis perforans serpiginosa (EPS) is now a well-recognized potential complication of long-term penicillamine therapy. By itself, EPS appears to be a relatively innocuous cutaneous side effect of penicillamine. However, suspicion has been raised in recent literature that EPS may represent only a superficial manifestation of more serious penicillamine-induced systemic elastic tissue damage, particularly involving blood vessels. This is a report of a patient with Wilson's disease who was treated with penicillamine for 14 years. She developed EPS, and histologic examination of the skin revealed the characteristic penicillamine-induced "lumpy-bumpy" elastic fibers in the dermis. More important, nonlesional skin showed the same elastic fiber changes. Of greatest significance was the finding of identical elastic fiber alterations in an artery.

PMID:: 3766920; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Case Reports

MeSH Terms

Substances

Penicillamine

LinkOut - more resources

Full Text Sources

Medical

Skin Conditions - MedlinePlus Health Information

Molecular Biology Databases

(D)-PENICILLAMINE - HSDB

Supplemental Content

Related citations

"Lumpy-bumpy" elastic fibers in the skin and lungs of a patient with a penicillamine-induced elastosis perforans serpiginosa. [J Cutan Pathol. 1979]
"Lumpy-bumpy" elastic fibers in the skin and lungs of a patient with a penicillamine-induced elastosis perforans serpiginosa.
Bardach H, Gebhart W, Niebauer G. J Cutan Pathol. 1979 Aug; 6(4):243-52.
Penicillamine-induced elastosis perforans serpiginosa with abnormal "lumpy-bumpy" elastic fibers in lesional and non-lesional skin. [Indian J Dermatol Venereol Leprol. 2011]
Penicillamine-induced elastosis perforans serpiginosa with abnormal "lumpy-bumpy" elastic fibers in lesional and non-lesional skin.
Khatu SS, Dhurat RS, Nayak CS, Pereira RR, Kagne RB. Indian J Dermatol Venereol Leprol. 2011 Jan-Feb; 77(1):55-8.
Penicillamine-induced elastosis perforans serpiginosa treated successfully with isotretinoin. [Dermatology. 1994]
Penicillamine-induced elastosis perforans serpiginosa treated successfully with isotretinoin.
Ratnavel RC, Norris PG. Dermatology. 1994; 189(1):81-3.
Review D-penicillamine-induced elastosis perforans serpiginosa in a child with juvenile rheumatoid arthritis. Report of a case and review of the literature. [J Am Acad Dermatol. 1989]
Review D-penicillamine-induced elastosis perforans serpiginosa in a child with juvenile rheumatoid arthritis. Report of a case and review of the literature.
Sahn EE, Maize JC, Garen PD, Mullins SC, Silver RM. J Am Acad Dermatol. 1989 May; 20(5 Pt 2):979-88.
Review D-penicillamine elastosis perforans serpiginosa: description of two cases and review of the literature. [Dermatol Online J. 2011]
Review D-penicillamine elastosis perforans serpiginosa: description of two cases and review of the literature.
Atzori L, Pinna AL, Pau M, Aste N. Dermatol Online J. 2011 Apr 15; 17(4):3. Epub 2011 Apr 15.

See reviews... See all...

Cited by 1 PubMed Central article

Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease. [Ann Dermatol. 2010]
Penicillamine-induced Elastosis Perforans Serpiginosa and Cutis Laxa in a Patient with Wilson's Disease.
Na SY, Choi M, Kim MJ, Lee JH, Cho S. Ann Dermatol. 2010 Nov; 22(4):468-71. Epub 2010 Nov 5.

Chemical compound information

Penicillamine

MW: 149.21 g/mol

MF: C₅H₁₁NO₂S

See 7 citations for this compound....

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Penicillamine-induced elastosis perforans serpiginosa. Tip of the iceberg?
Penicillamine-induced elastosis perforans serpiginosa. Tip of the iceberg?
Am J Dermatopathol. 1986 Aug ;8(4):314-20.

PubMed
Night light alters menstrual cycles.
Night light alters menstrual cycles.
Psychiatry Res. 1990 Aug ;33(2):135-8.

PubMed
Ossicular reconstruction in ears with cholesteatoma.
Ossicular reconstruction in ears with cholesteatoma.
Otolaryngol Clin North Am. 1989 Oct ;22(5):1003-13.

PubMed
A risk-benefit assessment of topical percutaneous local anaesthetics in children...
A risk-benefit assessment of topical percutaneous local anaesthetics in children.
Drug Saf. 1997 Apr ;16(4):279-87.

PubMed
Vapocoolant spray is equally effective as EMLA cream in reducing immunization pa...
Vapocoolant spray is equally effective as EMLA cream in reducing immunization pain in school-aged children.
Pediatrics. 1997 Dec ;100(6):E5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: