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Neurosci Lett. 1986 Sep 12;69(3):244-8.

Induction of hippocampal long-term potentiation using physiologically patterned stimulation.

Abstract

Lasting increases in the population spike recorded in area CA1 of hippocampal slices may be evoked by the patterned presentation of as few as 5 stimulus pulses delivered to the commissural/associational afferents. The most effective pattern of stimulus presentation was a single priming pulse followed 170 ms later by 4 pulses at 100 Hz; control trains of 5 pulses at 100 Hz had no significant enduring effect. This pattern-dependent phenomenon, termed primed burst potentiation, is of lesser magnitude than is the long-term potentiation induced by 100 Hz/l s stimulation, but appears to show a similar time course and duration. In addition, the two phenomena are not additive, suggesting that they may share a common mechanism.

PMID:
3763054
[PubMed - indexed for MEDLINE]
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