Neurology. 1986 Nov;36(11):1418-23.

Tight linkage of apolipoprotein C2 to myotonic dystrophy on chromosome 19.

Pericak-Vance MA, Yamaoka LH, Assinder RI, Hung WY, Bartlett RJ, Stajich JM, Gaskell PC, Ross DA, Sherman S, Fey GH, et al.

Abstract

The cDNA and genomic probes for apolipoprotein C2 detect two restriction fragment length polymorphisms on chromosome 19. The combined estimated percentage of heterozygosity, assuming equilibrium, is approximately 75%, ie, apolipoprotein C2 is informative in 75% of matings. We have analyzed over 350 individuals in large multigenerational families for linkage of apolipoprotein C2 to myotonic muscular dystrophy. The maximum lod score was 16.29 with the maximum recombination fraction (theta) of 0.02, with 95% confidence limits for theta of 0.001 to 0.065. Thus, apolipoprotein C2 is useful in carrier detection and prenatal diagnosis with an accuracy of about 98%.

PMID:: 3762959; [PubMed - indexed for MEDLINE]

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Linkage analysis of the apolipoprotein C2 gene and myotonic dystrophy on human chromosome 19 reveals linkage disequilibrium in a French-Canadian population. [Am J Hum Genet. 1989]
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Cited by 6 PubMed Central articles

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