Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome Caused by Apalutamide: A Case Presentation

Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe drug reaction that is triggered several weeks after the start of a new medication. This syndrome presents with a variety of clinical symptoms, specifically a manifestation involving a fever followed by a severe rash. A variety of medications are known to trigger DRESS, with the most common being anticonvulsants and allopurinol. Here, we discuss the case of a medication, apalutamide, that caused DRESS in our patient. Early recognition and abrupt discontinuation of the medication is required for the management of this syndrome and to minimize morbidity and mortality.