Spread of multidrug resistance in non-PCV13/PCV20 serotypes of Streptococcus pneumoniae: A cross-sectional study ten years after the introduction of pneumococcal conjugate vaccine in Japan

Mitsuyo Kawaguchiya; Noriko Urushibara; Meiji Soe Aung; Nobuhide Ohashi; Rika Takamatsu; Sho Tsutida; Masahiko Ito; Nobumichi Kobayashi

doi:10.1016/j.jmii.2023.07.004

Spread of multidrug resistance in non-PCV13/PCV20 serotypes of Streptococcus pneumoniae: A cross-sectional study ten years after the introduction of pneumococcal conjugate vaccine in Japan

J Microbiol Immunol Infect. 2023 Dec;56(6):1288-1292. doi: 10.1016/j.jmii.2023.07.004. Epub 2023 Jul 20.

Authors

Mitsuyo Kawaguchiya¹, Noriko Urushibara², Meiji Soe Aung², Nobuhide Ohashi², Rika Takamatsu³, Sho Tsutida³, Masahiko Ito³, Nobumichi Kobayashi²

Affiliations

¹ Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan. Electronic address: kawaguchiya@sapmed.ac.jp.
² Department of Hygiene, Sapporo Medical University School of Medicine, Sapporo, Japan.
³ Sapporo Mirai Laboratory, Co. Ltd., Sapporo, Japan.

PMID: 37517964
DOI: 10.1016/j.jmii.2023.07.004

Abstract

Ten years after the introduction of the pneumococcal conjugate vaccine (PCV) in Japan, the prevalence rates of non-PCV13 and non-PCV20 serotypes among pediatric pneumococcal isolates were 94.0% and 73.7%, respectively. The predominant non-PCV13/PCV20 serotypes (15A, 35B, and 23A) were mostly multidrug-resistant (≥80.5%), exhibiting non-susceptibility to penicillin.

Keywords: Antimicrobial susceptibility; Japan; Pneumococcal conjugate vaccines (PCVs); Serotype; Streptococcus pneumoniae.

MeSH terms

Child
Cross-Sectional Studies
Drug Resistance, Multiple
Humans
Japan / epidemiology
Pneumococcal Infections* / epidemiology
Pneumococcal Infections* / prevention & control
Pneumococcal Vaccines
Serogroup
Serotyping
Streptococcus pneumoniae*
Vaccines, Conjugate

Substances

Vaccines, Conjugate
Pneumococcal Vaccines