A case of retroperitoneal liposarcoma consisting of three large nodules with three different types of histologic findings is presented. A 69-year-old man was diagnosed as having a malignant tumor in the retroperitoneum and underwent successful tumor extirpation. The resected tumor had three different type of nodules, 18 X 15 X 7.0 cm, 8 X 15 X 4.0 cm, 15 X 10 X 2.5 cm in size, respectively. The histologic examination revealed myxoid, well-differentiated fibrosing and lipoma-like liposarcoma type, respectively. Chemotherapy was undertaken postoperatively, and there is no evidence of recurrence two years after surgery.