Intraoperative Molecular Imaging of Lung Cancer

Lye-Yeng Wong; Natalie S Lui

doi:10.1016/j.thorsurg.2023.04.013

Intraoperative Molecular Imaging of Lung Cancer

Thorac Surg Clin. 2023 Aug;33(3):227-232. doi: 10.1016/j.thorsurg.2023.04.013. Epub 2023 May 29.

Authors

Lye-Yeng Wong¹, Natalie S Lui²

Affiliations

¹ Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Falk Building, Stanford, CA 94305, USA. Electronic address: https://twitter.com/LyeYengWongMD.
² Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Drive, Falk Building, Stanford, CA 94305, USA. Electronic address: natalielui@stanford.edu.

PMID: 37414478
DOI: 10.1016/j.thorsurg.2023.04.013

Abstract

Intraoperative molecular imaging innovations have been propelled by the development of fluorescent contrast agents that specifically target tumor tissues and advanced camera systems that can detect the specified fluorescence. The most promising agent to date is OTL38, a targeted and near-infrared agent that was recently approved by the Food and Drug Administration for intraoperative imaging for lung cancer.

Keywords: EC 17; Fluorescence; Indocyanine green; Intraoperative molecular imaging; OTL38; Thoracic surgery.

Publication types

Review

MeSH terms

Fluorescent Dyes
Humans
Lung Neoplasms* / diagnostic imaging
Lung Neoplasms* / surgery
Molecular Imaging / methods
Optical Imaging / methods

Substances

Pafolacianine
Fluorescent Dyes