Correlation of polypill and blood pressure level: A systematic review of clinical trials

Hamidreza Omrani; Mostafa Bahremand; Fatemeh Keshavarzi; Leila Solouki; Ehsan Zereshki

doi:10.4103/jehp.jehp_845_22

Correlation of polypill and blood pressure level: A systematic review of clinical trials

J Educ Health Promot. 2023 May 31:12:171. doi: 10.4103/jehp.jehp_845_22. eCollection 2023.

Authors

Hamidreza Omrani¹, Mostafa Bahremand¹, Fatemeh Keshavarzi², Leila Solouki², Ehsan Zereshki¹

Affiliations

¹ Cardiovascular Research Center, Health Institute, Imam-Ali Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran.
² Student Research Committee, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.

Abstract

Background: High blood pressure (BP) is considered as the most important risk factor for cardiovascular disease (CVD). The main aim of this study was to investigate the effect of polypill on BP by reviewing clinical trial studies.

Materials and methods: In this systematic review study, online databases such as PubMed, Scopus, and Web of Science databases with no limited time were systematically searched until July 10, 2020. Clinical trial studies published in English that examined the effect of polypill on BP were included. BP was the main outcome investigated.

Results: Eleven original articles with a population of 17,042 people were reviewed. The polypill drugs studied in this study had different compounds. Compared to conventional care, treatment with polypill compounds has a positive and significant effect on lowering BP (P < 0.05).

Conclusion: Our finding confirmed that polypills could reduce BP in patients. It seems that changing routine care and replacing it with a polypill strategy could facilitate the achievement of BP control goals.

Keywords: Blood pressure; clinical trial; polypill; systematic review.