Acute-on-chronic liver failure (ACLF) is a clinical syndrome of acute decompensation accompanied by organ failure that occurs on the basis of chronic liver disease and has a high short-term mortality rate. Currently, there are still differences in relation to the definition of ACLF; thus, baseline characteristics and dynamic changes are important bases for clinical decision-making in patients with liver transplantation and others. The basic strategies for treating ACLF currently include internal medicine treatment, artificial liver support systems, and liver transplantation. Multidisciplinary active collaborative management throughout the whole course is of great significance for further improving the survival rate in patients with ACLF.
慢加急性肝衰竭（ACLF）是在慢性肝病基础上发生的急性失代偿并伴有器官衰竭的临床综合征，短期病死率高。目前有关ACLF的定义尚存差异，患者基线特征和动态变化是肝移植等临床决策的重要基础。包括内科治疗、人工肝支持系统在内的脏器支持治疗与肝脏移植是目前ACLF治疗的基本策略。贯穿全程的多学科积极协作管理，对于进一步提高ACLF患者的生存率具有重要意义。.
Keywords: Acute-on-chronic liver failure; Artificial liver; Liver transplantation; Treatment.