Recent research advances in ATX inhibitors: An overview of primary literature

Cheng Zhang; Yue Liu; Qinjiang Zhou; Hongze Fan; Xiaoxiao Liu; Jinxing Hu

doi:10.1016/j.bmc.2023.117374

Recent research advances in ATX inhibitors: An overview of primary literature

Bioorg Med Chem. 2023 Jul 15:90:117374. doi: 10.1016/j.bmc.2023.117374. Epub 2023 Jun 15.

Authors

Cheng Zhang¹, Yue Liu¹, Qinjiang Zhou¹, Hongze Fan¹, Xiaoxiao Liu², Jinxing Hu³

Affiliations

¹ Weifang Medical University, No. 7166 Baotong Road, Weifang 261053, PR China.
² Weifang Medical University, No. 7166 Baotong Road, Weifang 261053, PR China. Electronic address: liuxx@wfmc.edu.cn.
³ Weifang Medical University, No. 7166 Baotong Road, Weifang 261053, PR China. Electronic address: jinxinghu2013@wfmc.edu.cn.

PMID: 37354726
DOI: 10.1016/j.bmc.2023.117374

Abstract

The autoglobulin gene is the main enzyme for circulating LPA production and has lysophosphatidylcholine D activity, which catalyzes the production of lysophosphatidic acid and choline with lysophosphatidylcholine as substrate. A growing body of experimental evidence suggests that autoglobulin is involved in the pathogenesis of a variety of diseases. This review summarizes the different structural ATX inhibitors classified according to their binding mode to the ATX triple orientation site, and summarizes the conformational relationships and molecular docking of each type with ATX structure, hoping to contribute to the development of novel ATX inhibitors.

Keywords: Autotaxin (ATX); Inhibitors; Lysophosphatidic acid (LPA); Lysophosphatidylcholine (LPC).

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Lysophosphatidylcholines* / metabolism
Lysophospholipids / metabolism
Molecular Docking Simulation
Phosphoric Diester Hydrolases* / metabolism

Substances

Phosphoric Diester Hydrolases
Lysophosphatidylcholines
Lysophospholipids