Psychol Med. 1986 May;16(2):323-9.

Dextroamphetamine-induced arousal in human subjects as a model for mania.

Abstract

Because of the practical difficulties which arise in studying manic patients, a reproducible model for mania using human subjects would be a valuable adjunct to research in this condition. Dextroamphetamine, given as a single oral 20 mg dose, fulfils the criteria for such a model in that there are very close similarities between the changes which occur after dextroamphetamine and those which have been observed in mania in terms of subjective experience, physiological and endocrine changes, and response to pharmacological agents.

PMID:: 3726006; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Medical

Bipolar Disorder - MedlinePlus Health Information

Molecular Biology Databases

DEXTROAMPHETAMINE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Subjective responses to d-amphetamine alone and after pimozide pretreatment in normal, healthy volunteers. [Biol Psychiatry. 1996]
Subjective responses to d-amphetamine alone and after pimozide pretreatment in normal, healthy volunteers.
Brauer LH, de Wit H. Biol Psychiatry. 1996 Jan 1; 39(1):26-32.
Valproate attenuates dextroamphetamine-induced subjective changes more than lithium. [Eur Neuropsychopharmacol. 2005]
Valproate attenuates dextroamphetamine-induced subjective changes more than lithium.
Willson MC, Bell EC, Dave S, Asghar SJ, McGrath BM, Silverstone PH. Eur Neuropsychopharmacol. 2005 Dec; 15(6):633-9. Epub 2005 Jun 9.
Diltiazem, a calcium antagonist, partly attenuates the effects of dextroamphetamine in healthy volunteers. [Int Clin Psychopharmacol. 1997]
Diltiazem, a calcium antagonist, partly attenuates the effects of dextroamphetamine in healthy volunteers.
Fabian JE, Silverstone PH. Int Clin Psychopharmacol. 1997 Mar; 12(2):113-20.
Review A rapid and systematic review and economic evaluation of the clinical and cost-effectiveness of newer drugs for treatment of mania associated with bipolar affective disorder. [Health Technol Assess. 2004]
Review A rapid and systematic review and economic evaluation of the clinical and cost-effectiveness of newer drugs for treatment of mania associated with bipolar affective disorder.
Bridle C, Palmer S, Bagnall AM, Darba J, Duffy S, Sculpher M, Riemsma R. Health Technol Assess. 2004 May; 8(19):iii-iv, 1-187.
Review [Antipsychotics in bipolar disorders]. [Encephale. 2004]
Review [Antipsychotics in bipolar disorders].
Vacheron-Trystram MN, Braitman A, Cheref S, Auffray L. Encephale. 2004 Sep-Oct; 30(5):417-24.

See reviews... See all...

Cited by 11 PubMed Central articles

Better than I thought: positive evaluation bias in hypomania. [PLoS One. 2012]
Better than I thought: positive evaluation bias in hypomania.
Mason L, O'Sullivan N, Bentall RP, El-Deredy W. PLoS One. 2012; 7(10):e47754. Epub 2012 Oct 17.
Dysregulated glutamate and dopamine transporters in postmortem frontal cortex from bipolar and schizophrenic patients. [J Affect Disord. 2012]
Dysregulated glutamate and dopamine transporters in postmortem frontal cortex from bipolar and schizophrenic patients.
Rao JS, Kellom M, Reese EA, Rapoport SI, Kim HW. J Affect Disord. 2012 Jan; 136(1-2):63-71. Epub 2011 Sep 16.
Behavioral and pharmacological assessment of a potential new mouse model for mania. [Physiol Behav. 2011]
Behavioral and pharmacological assessment of a potential new mouse model for mania.
Scotti MA, Lee G, Stevenson SA, Ostromecki AM, Wied TJ, Kula DJ, Gessay GM, Gammie SC. Physiol Behav. 2011 Jun 1; 103(3-4):376-83. Epub 2011 Mar 22.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Dextroamphetamine-induced arousal in human subjects as a model for mania.
Dextroamphetamine-induced arousal in human subjects as a model for mania.
Psychol Med. 1986 May ;16(2):323-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: