Neuroprotective mechanisms of Asiatic acid

Liuyun Ding; Tiantian Liu; Jin Ma

doi:10.1016/j.heliyon.2023.e15853

Neuroprotective mechanisms of Asiatic acid

Heliyon. 2023 Apr 26;9(5):e15853. doi: 10.1016/j.heliyon.2023.e15853. eCollection 2023 May.

Authors

Liuyun Ding¹, Tiantian Liu², Jin Ma¹

Affiliations

¹ Department of Emergency Medicine, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, 215300, China.
² Shanghai Seventh's People's Hospital, An Affiliate of Shanghai University of Traditional Chinese Medicine, Shanghai, 200137, China.

Abstract

Asiatic acid (AA) is the most crucial component of Asiaticoside in many edible and medicinal plants. It has diverse biological activities such as anti-inflammatory, antioxidant, anti-infective, and anti-tumor. Additionally, AA has been intensively studied in the last decades. It has shown great potential in the treatment of various neurological diseases such as spinal cord injury (SCI), cerebral ischemia, epilepsy, traumatic brain injury (TBI), neural tumors, Alzheimer's disease (AD), and Parkinson's disease (PD). Moreover, AA provides pertinent data for neuroprotective signaling pathways, and its substantial neuroprotective ability makes it a novel candidate for developing drugs that target the central nervous system.

Keywords: Asiatic acid; Central nervous system; Molecular targets; Neuroprotection; Signaling pathways.

Publication types

Review