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J Neural Transm. 1986;65(3-4):303-26.

Prenatal developmental disturbances in the limbic allocortex in schizophrenics.

Abstract

Sixty-four autopsied brains of schizophrenic patients were neuropathologically examined and compared with 10 brains of non-schizophrenic controls. Clinical diagnoses were established retrospectively according to the Research Diagnostic Criteria and the International Classification of Diseases. We found: brains without deviations of the sulcogyral pattern of the temporal lobe or abnormal gross configuration (n = 22); brains with abnormal sulcogyral pattern of the temporal lobe or abnormal gross configuration (n = 42): with definite cytoarchitectonic abnormalities of the rostral entorhinal region in the parahippocampal gyrus and, in 16 cases only, in the ventral insular cortex (n = 20); with equivocal changes of the cytoarchitecture in these two regions (n = 22). Generally, these anatomical abnormalities were asymmetric. The histological findings in the two limbic regions consisted mainly of poorly developed structure in the upper layers, with a heterotopic displacement of single groups of nerve cells in the entorhinal region. Particularly, the disturbed structure of the second layer Pre-alpha in medial and central fields of the entorhinal region, situated in the parahippocampal gyrus (group 2a), suggests a disturbance of neuronal migration in a later phase of cortical development.

PMID:
3711886
[PubMed - indexed for MEDLINE]
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