FEBS Lett. 1986 May 26;201(1):20-4.

Peroxisomal alanine:glyoxylate aminotransferase deficiency in primary hyperoxaluria type I.

Abstract

Activities of alanine:glyoxylate aminotransferase in the livers of two patients with primary hyperoxaluria type I were substantially lower than those found in five control human livers. Detailed subcellular fractionation of one of the hyperoxaluric livers, compared with a control liver, showed that there was a complete absence of peroxisomal alanine:glyoxylate aminotransferase. This enzyme deficiency explains most of the biochemical characteristics of the disease and means that primary hyperoxaluria type I should be added to the rather select list of peroxisomal disorders.

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Enzymatic heterogeneity in primary hyperoxaluria type 1 (hepatic peroxisomal alanine: glyoxylate aminotransferase deficiency). [J Inherit Metab Dis. 1988]
Enzymatic heterogeneity in primary hyperoxaluria type 1 (hepatic peroxisomal alanine: glyoxylate aminotransferase deficiency).
Danpure CJ, Jennings PR. J Inherit Metab Dis. 1988; 11 Suppl 2:205-7.
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Review Primary hyperoxaluria type 1 and peroxisome-to-mitochondrion mistargeting of alanine:glyoxylate aminotransferase.
Danpure CJ. Biochimie. 1993; 75(3-4):309-15.

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