[Benzoxazolinone phenylethanolamine antagonists of adrenergic receptors. A chemical and pharmacodynamic study]

M P Vaccher; D Lesieur; C Lespagnol; J P Bonte; J C Lamar; M Beaughard; G Dureng

[Benzoxazolinone phenylethanolamine antagonists of adrenergic receptors. A chemical and pharmacodynamic study]

Farmaco Sci. 1986 Apr;41(4):257-69.

[Article in French]

Authors

M P Vaccher, D Lesieur, C Lespagnol, J P Bonte, J C Lamar, M Beaughard, G Dureng

PMID: 3709788

Abstract

Benzoxazolinone can be considered as a bioisosteric analogue of pyrocatechol. This concept has led to the synthesis of benzoxazolinonic phenylethanolamines. The pharmacological study shows that these compounds possess an affinity for adrenergic receptors. Compound (XXXIV), the most interesting, is a competitive alpha and beta adrenergic antagonist which has been studied for antihypertensive activity.

Publication types

English Abstract

MeSH terms

Animals
Antihypertensive Agents / chemical synthesis
Chemical Phenomena
Chemistry
Dogs
Ethanolamines / chemical synthesis*
Ethanolamines / pharmacology
Guinea Pigs
In Vitro Techniques
Male
Oxazoles / chemical synthesis*
Oxazoles / pharmacology
Phenethylamines / chemical synthesis*
Phenethylamines / pharmacology
Rats
Sympatholytics / chemical synthesis*

Substances

Antihypertensive Agents
Ethanolamines
Oxazoles
Phenethylamines
Sympatholytics